Diprogenta is the trade name for the combination of betamethasone dipropionate and gentamicin sulfate. It is a drug that has been designed to treat skin inflammations that are also accompanied by infections. It comes in the form of a cream, so it only has topical use, that is, external.
Based on the above, it can be said that Diprogenta is a product that should not be ingested, since it is a solely and exclusively dermatological drug; that is, it is only used to be used on the skin.
Furthermore, Diprogenta has pharmacochemical properties that must be carefully observed before being administered in cases where there are clear contraindications and warnings of adverse reactions (in other words, side effects)..
Also, Diprogenta has pharmacological aspects that should not be overlooked. Although this cream does not have any known interaction with other products, Diprogenta has toxicological repercussions on the human body..
That is to say, in doses higher than those indicated by the doctor, this medicine can negatively affect the health of the patient, especially if its treatment is carried out without the proper supervision of the dermatologist..
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Diprogenta is a cream composed of a corticosteroid (a type of steroid) that has anti-inflammatory properties and an antibiotic that fights bacterial infections. As already mentioned, there are two active ingredients in Diprogenta: betamethasone dipropionate and gentamicin sulfate..
Each gram of this medicine is distributed respectively in 0.5 milligrams of the first and 1 milligram of the second, not including the excipients that are contained within the formula..
Excipients serve multiple purposes that cannot be described here. But it is worth noting that Diprogenta has, for example, purified water (or distilled, as it is also known), white petroleum jelly (which explains the color and texture of the cream), ether, phosphoric acid and liquid paraffin, without mention others more.
These ingredients appear equally in the Diprogenta presentations, as in the 30-gram tubes and in the 60-gram tubes, among others..
There are two main properties of Diprogenta: the pharmacodynamic, related to the physiological and biochemical effects, and the pharmacokinetic, related to the displacement of the drug in the human body..
In pharmacodynamics, Diprogenta is characterized by having anti-inflammatory, immunosuppressive, antiproliferative and bactericidal properties. This means, in other words, that this drug not only deflates the skin, but it rid of harmful microorganisms.
On the other hand, the pharmacokinetic properties of Diprogenta imply that they have an easier and faster absorption when the skin where it is applied is healthy. There are several factors that can alter this process, but in general it develops normally, that is, the active principles of the cream pass into the bloodstream, then into the liver and from there are expelled through the urine (in laboratory experiments carried out in mice, it is from bile).
All the studies that have been carried out in humans have undoubtedly shown that the best route of application of Diprogenta is the topical, which is external, instead of the oral route..
This is so for a compelling reason; because the active principles of this cream are not well absorbed in the intestines, hence it does not make sense that this drug is manufactured in tablets. Consequently, Diprogenta has been shown to be better metabolized in the skin..
Diprogenta is used mainly in those skin conditions that are inflammatory such as dermatosis, which is a disorder that yields to the action of the active principles of this cream.
It is also used to fight psoriasis, dermatitis, and other skin diseases caused by any kind of microorganisms that are vulnerable to gentamicin. In no way should this medicine be used outside of these specifications (see section 7)..
Although the exact dose of Diprogenta is determined by the doctor for sure, it is usually administered in adults and young people over 12 years of age (there are contraindications for children, see sections 5 and 7, below). twice daily.
This application should only be done on the affected area, with thin layers of cream covering the skin lesion. It is recommended that the treatment last no more than two weeks.
Apart from the universal prohibition in case of allergy to the components (which is common in medicines), the use of Diprogenta is contraindicated in the following circumstances:
Diprogenta does not have any undesirable effect on the patient when driving machines and vehicles, hence it can be used without problems in this regard. However, this cream may have adverse reactions that do not occur in all people, but in very exceptional or specific cases..
For example, Diprogenta can cause changes in skin color and even allergies, but these symptoms are rare and therefore do not appear very frequently..
Although Diprogenta can cause itching, swelling with red spots (erythema), tenderness, and irritation, these symptoms of gentamicin treatment have rarely been a reason to stop using this medicine..
However, the abuse of corticosteroids, as well as their use in large areas, especially if it is with dressings (external use remedies that are covered with bandages, gauze, etc.), can lead to various adverse reactions on the skin. , such as:
Additionally, the absorption of Diprogenta through the skin can also generate adverse reactions that extend to various parts of the human body that are not treated in the patient..
This happens because the active ingredients dissolve and pass into the bloodstream, which means that they are distributed or concentrated in other organs and tissues that are healthy. Consequently, additional effects may occur from the use of corticosteroids. Among them are:
There are adverse effects of Diprogenta that are not related to its use according to the doses indicated by the doctor, but due to overdose.
A single overdose is not enough to cause serious disorders as these are completely reversible by treatment that relieves symptoms. But an indiscriminate use of Diprogenta can cause alterations in the functions of the kidneys, apart from lesions on the skin due to bacteria and fungi (that is, bacterial resistance).
Above all, the use of Diprogenta must take into account the aforementioned contraindications and adverse reactions that were explained above, especially in pregnancy, lactation and in children under 12 years of age..
In special cases where there may be an allergy or hypersensitivity to the components of this drug, it is preferable that its use is under the guidance of a doctor who makes an objective balance of the risks and benefits of said drug..
However, it should be noted that there are a number of highly recommended measures and considerations when using Diprogenta, which must be followed to the letter. These are:
As far as it has been known, Diprogenta cream does not have any kind of interaction with other medications, regardless of their type. Diprogenta has not been shown to interact with other chemicals that can be ingested orally, such as alcohol or drugs..
In any case, it is highly recommended that the patient tell his doctor if he is taking drugs, in order to evaluate potential adverse effects with their application on the skin.
This article is only intended to give general information about Diprogenta, hence the pharmaceutical terminology will not be used much. Since Diprogenta is a product that comes in different presentations, it will be discussed in a very global way.
It should be noted that Diprogenta is a registered trademark in the name of the defunct Schering-Plow, so this writing is not an official publication of the company and its author does not act on its behalf.
It is worth saying that you consult a specialist first if you have an ailment that can be treated with Diprogenta; do not use if you do not need it or if your doctor has not told you.
It is also important to limit what the leaflets that are printed on all medicines say: it is necessary that you always go to the doctor if there are adverse effects, if you have an allergy to any of its components and if you are pregnant or breastfeeding. See references section for details.
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