The lincomycin is a natural antibiotic belonging to the group of lincosamides, which is extracted from a bacteria called Streptomyces lincolnensis. Se can be administered orally, intramuscularly or intravenously.
It is an antibiotic indicated in the treatment of serious infections caused by sensitive gram-positive aerobic strains, such as streptococci, pneumococci and staphylococci, or by susceptible anaerobic bacteria.
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It is normally indicated in patients allergic to penicillin or in cases where the doctor considers that the use of penicillin is not adequate. It is easily absorbed by most tissues, so it is effective in treating infections caused by germs sensitive to this substance, such as:
Lincomycin is not indicated for the treatment of mild or viral infections..
Orally, the presentation of lincomycin (capsules) usually contains lactose, so it is contraindicated in patients with intolerance to this component.
The injectable solution presentation contains benzyl alcohol, so it should not be administered to premature infants or infants less than one month old..
It should not be administered in patients who are hypersensitive or allergic to this active principle or to clindamycin. It should also not be given to people who have or have had monilial infections. It is not indicated in patients with meningitis or acute renal failure..
Lincomycin should be administered with great care in people with the following conditions:
There is a risk of pseudomembranous colitis and growth of non-susceptible organisms. The treating physician must make a functional assessment of the involved organs before and during treatment with lincomycin, especially if it must be prolonged. It is suggested to perform liver, kidney and blood count tests regularly..
As with other antibiotics, lincomycin treatment has been associated with episodes of severe colitis, which can be life-threatening. In the event of diarrhea, stop treatment immediately and consult a doctor..
Like any other drug, lincomycin should be administered by prescription and medical monitoring during pregnancy and lactation..
Although a study carried out in 322 pregnant women who were administered 500 milligrams of lincomycin four times a day for a week did not present any harmful effects on the mother or the fetus, there are no sufficiently controlled and documented studies, so there are no can guarantee its safety in the fetus.
In the case of breastfeeding, the antibiotic is eliminated through breast milk, which is why it is considered incompatible with breastfeeding and it is necessary to resort to substitute medications or suspend breastfeeding..
Lincomycin alters (raises) the analytical values of transaminases (ALT / SGGPT AST / SGOT) and alkaline phosphatase in the blood. It antagonizes erythromycin and is cross-resistant when co-administered with clindamycin. It also interacts with the following medications or components:
Finally, the absorption of lincomycin is reduced if it is administered together with antidiarrheals that reduce intestinal motility or absorbents, so it is recommended to avoid the intake of food or beverages from two hours before to two hours after taking the drug..
The intake of alcoholic beverages together with this antibiotic increases the risk of side effects.
Like any medicine, lincomycin can produce certain adverse reactions that may appear more or less frequently in each patient, ranging from very common (more than 1 in 10 patients), frequent (1-10 in 100 patients), uncommon ( 1-10 out of 1000 patients), rare (1-10 out of 10,000 patients) and very rare (less than 1 in 10,000 patients).
Some of these adverse reactions can be:
Although side effects usually occur at the time of administration of the drug, in some cases they can occur up to several weeks after you have stopped taking it..
Lincomycin can be presented in capsules (500mg) and injectable ampoules (600mg / 2 ml intramuscular or intravenous).
Like most antibiotics, it is advisable to complete the treatment indicated by the doctor, even when the symptoms of the disease for which they were prescribed have diminished or disappeared completely..
This becomes much more important in the case of treatment for streptococcal infection; Serious heart problems can develop in the medium or long term if the infection has not been completely cured.
It is also important to comply with the periodicity in the intake or application of the drug, since it works better when there is a constant amount in the blood. If a dose is missed it should be taken as soon as possible.
However, doubling the dose is not recommended in the case of longer forgetfulness. It is advisable in these cases to allow 2 to 4 hours to pass between the forgotten dose and the next one..
If any allergic reaction or abnormality is observed after the administration of the medicine, its use should be stopped immediately and consult with the doctor..
An experiment in rats carried out in Brazil concluded that the use of topical lincomycin is effective in repairing the periodontal ligament and restoring the dentoalveolar joint, in addition to reducing inflammation in cases of dental reimplantation.
Used in veterinary medicine, lincomycin has been shown to be effective in the control of respiratory diseases in pigs and for the promotion of growth, mainly in the pig starter stage..
It has also been used successfully in uncomplicated superficial cases of canine pyoderma, one of the most common skin diseases in dogs..
The use of lincomycin has been found to be highly effective in the treatment of acute tonsillitis and acute sinusitis..
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