Cyclofemina What is it for, Effects and Contraindications

1327
Alexander Pearson

The cyclofemin It is a combined hormonal type medicine for parenteral use. It is a comfortable and safe alternative for the treatment of menstrual dysfunction, contraception and hormone replacement therapy. Intramuscular administration is an advantage over oral hormonal preparations.

The drug is a combination of two active ingredients -medroxyprogesterone and estradiol-, which ensures its effectiveness. Both hormones are presented in an aqueous suspension for monthly injection. The joint action of two hormones gives several mechanisms of action, constituting an advantage over simple preparations.

The development of cyclofemin is due to the Concept Foundation, a Thai organization supported by the World Health Organization. It was initially marketed in Indonesia and Mexico in 1993, and later distributed in other countries. In 1997 Concept Foundation obtained the rights to the drug, under the name Cyclofem®.

Around 16 million women in the world use injectable contraception, due to the convenience of its monthly or quarterly administration. In Latin America and China the use of injectable contraceptives is increasingly regular.

The need for effective birth control mechanisms makes cyclofemin a drug of choice for this purpose. Beyond contraception, the drug is also useful in pathologies related to menstrual function.

Article index

  • 1 What is it for?
    • 1.1 Composition
    • 1.2 Effect
    • 1.3 Uses
  • 2 Effectiveness
  • 3 Side effects
  • 4 Contraindications
  • 5 References

What is it for?

Medroxyprogesterone acetate, a component of cyclofemin

The usefulness of cyclofemin is determined by its composition and the effects it produces. The association of two hormonal compounds produces an additive effect that exceeds the effect of preparations with a single hormone.

Composition

Cyclofemin is made up of two hormones:

- Medroxyprogesterone Acetate, 25 mg.

- Estradiol cypionate, 5 mg (combination on which its effect is based).

Medroxyprogesterone is the most abundant progestin in women. Its biological function is related to the control of the menstrual cycle.

Estradiol is an estrogenic hormone with a wide range of effects on the female body, including sexual and reproductive function, protection of the skin and the cardiovascular system..

Effect

Both hormones are capable of inhibiting the effect of follicle-stimulating (FSH), luteinizing (LH) hormones and, to a lesser extent, chorionic gonadotropin. Consequently, there are three changes in female reproductive physiology:

- Inhibits the release of eggs from the ovarian follicle.

- Prevents proliferation of the endometrium.

- Increases the viscosity of cervical mucus.

Applications

The main use of cyclofemin is as a contraceptive, since it does not favor the female reproductive mechanism. The inhibition of ovulation, the barrier posed by the viscosity of the cervical mucus and the lack of endometrial proliferation are determining factors of the contraceptive effect..

Proper use prevents pregnancies in sexually active women, without causing effects on fertility after suspension..

The action on female hormones also involves other effects, useful for the treatment of menstrual dysfunction:

- Helps regulate menstrual cycles in women with abnormal cycles.

- Treatment of secondary amenorrhea.

- Avoid endometrial hyperplasia.

- Corrects abnormal uterine bleeding; that is, abundant or outside the period.

- It is used as hormone replacement therapy in women with total hysterectomy or menopause.

Effectiveness

The composition of cyclofemina, made up of 2 hormones, increases the effectiveness of the drug; the effectiveness of cyclofemin is estimated to be nearly 100%. However, the pregnancy rate of 0.1 to 0.2% can be observed before the first 6 months of continuous use..

Some medications can decrease the effectiveness of the hormonal compound, such as aminoglutetamide, which lowers the serum concentration of medroxyprogesterone. Other drugs that interact with cyclofemin by increasing its liver metabolism are:

- Ampicillin.

- Rifampicin.

- Chloramphenicol.

- Tetracyclines.

- Drugs like barbiturates.

- Benzodiazepines.

Side effects

Like most medicines, estradiol and medroxyprogesterone can cause unwanted effects. Although cyclofemin is well tolerated and the rate of side effects is low, it should be noted that these can occur.

The most severe and rapid complication produced by the administration of a drug is hypersensitivity, both to the active principle and to its vehicle..

In the case of cyclofemin, this can cause urticaria, facial, eyelid or limb edema, respiratory distress or cough. These symptoms should be treated as soon as they appear.

Other side effects, no less important, are:

- Changes in body weight, such as obesity.

- Hyporexia.

- Increase in blood glucose or lipids.

- Amenorrhea.

- Increased menstrual bleeding or short menstrual cycles.

- Tachycardia.

- Increased blood pressure.

- Headache.

- Dizziness.

- Varicose veins in lower limbs.

- Increased risk of thrombophlebitis and pulmonary thromboembolism.

- Body weakness.

- Depression.

- Insomnia.

It should be noted that other side effects occur related to the age and predisposition of each person. The increased risk for cardiovascular and cerebrovascular diseases is typical of the use of hormonal contraceptives after the age of 40.

Some types of cancer - such as cervical or breast cancer - have specific hormone receptors, so the use of cyclofemin could promote or worsen them.

Contraindications

Some clinical situations or conditions in women mean avoiding the administration of cyclofemin. Contraindications to the use of hormonal compounds arise because the risk of administration outweighs the benefit.

The medical history and the appropriate physical examination are the tools to determine the indication of the hormonal compound. The use of cyclofemina is contraindicated in the following situations:

- Hypersensitivity to the active substance or to the vehicle, due to the risk of presenting anaphylaxis.

- Pregnancy and breastfeeding. During pregnancy, it is not necessary to use hormones that could affect its normal development. Simple hormonal preparations are generally used in breastfeeding.

- Hormone-dependent reproductive system cancer.

- Breast cancer.

- Genital bleeding whose cause has not been specified.

- Endometrial hyperplasia of unknown origin.

- Galactorrhea not related to pregnancy or lactation.

- Cardiovascular diseases, such as high blood pressure or heart disease.

- Dyslipidemias, due to increased cardiovascular risk.

- Long-standing diabetes mellitus.

- Liver disease or failure.

- Gallstones or choledocholithiasis.

- History of vascular, arterial, or venous disease.

- Moderate to severe depression.

- Bronchial asthma.

References

  1. Tablet wise (s.f.). Cyclofemine injection: uses, side-effects, reviews and precautions. Recovered from tabletwise.com
  2. Concept Foundation (s.f.). Our history. Recovered from conceptfoundation.org
  3. Wikipedia. Estradiol Recovered from en.wikipedia.org
  4. Wikipedia. Medroxyprogesterone. Recovered from en.wikipedia.org
  5. Stacey, D (2018). Combined contraceptive injections. Ciclofem, lunelle and mesygina. Recovered from verywellhealth.com
  6. Simmons R; Fajans P; Lubis F (1994). Contraceptive introduction and the management of choice: the role of Cyclofem in Indonesia. Recovered from ncbi.nlm.nih.gov
  7. DeMayo FJ; Zhao B; Takamoto N; Tsai SY (2002). Mechanisms of action of estrogen and progesterone. Recovered from ncbi.nlm.nih.gov
  8. U.S. National library of medicine (s.f.). Pharmacokinetic and Pharmacodynamic Study of Cyclofem. Recovered from clinicaltrials.gov
  9. Wdrugs, reviewed by Narang, S (s.f.). Cyclofemina. Recovered from wdrugs.com
  10. Consortium for ememergency contraception in india. Injectable contraception. Recovered from aiims.edu
  11. d'Ancarges, C; Snow, R (1999) Injectable Contraceptives for Women. Recovered from gfmer.ch
  12. (s.f.) Cyclofemina uses. Recovered from ndrugs.com

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